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Lung B cells promote early pathogen dissemination and hasten death from inhalation anthrax.
- Source :
-
Mucosal immunology [Mucosal Immunol] 2012 Jul; Vol. 5 (4), pp. 444-54. Date of Electronic Publication: 2012 Apr 04. - Publication Year :
- 2012
-
Abstract
- Sampling of mucosal antigens regulates immune responses but may also promote dissemination of mucosal pathogens. Lung dendritic cells (LDCs) capture antigens and traffic them to lung-draining lymph nodes (LDLNs) dependent on the chemokine receptor CCR7 (chemokine (C-C motif) receptor 7). LDCs also capture lung pathogens such as Bacillus anthracis (BA). However, we show here that the initial traffic of BA spores from lungs to LDLNs is largely independent of LDCs and CCR7, occurring instead in association with B cells. BA spores rapidly bound B cells in lungs and cultured mouse and human B cells. Binding was independent of the B-cell receptor (BCR). B cells instilled in the lungs trafficked to LDLNs and BA spore traffic to LDLNs was impaired by B-cell deficiency. Depletion of B cells also delayed death of mice receiving a lethal BA infection. These results suggest that mucosal B cells traffic BA, and possibly other antigens, from lungs to LDLNs.
- Subjects :
- Animals
Anthrax microbiology
Anthrax mortality
B-Lymphocytes metabolism
Cell Line
Dendritic Cells immunology
Dendritic Cells metabolism
Disease Models, Animal
Immunoglobulin M immunology
Immunoglobulin M metabolism
Lung microbiology
Lymph Nodes immunology
Lymph Nodes metabolism
Lymphocyte Depletion
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Receptors, Antigen, B-Cell immunology
Receptors, Antigen, B-Cell metabolism
Receptors, CCR7 immunology
Receptors, CCR7 metabolism
Receptors, Complement immunology
Receptors, Complement metabolism
Spores, Bacterial immunology
Anthrax immunology
B-Lymphocytes immunology
Bacillus anthracis immunology
Lung immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1935-3456
- Volume :
- 5
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Mucosal immunology
- Publication Type :
- Academic Journal
- Accession number :
- 22472773
- Full Text :
- https://doi.org/10.1038/mi.2012.21