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Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer.

Authors :
Urbanska AM
Karagiannis ED
Guajardo G
Langer RS
Anderson DG
Source :
Biomaterials [Biomaterials] 2012 Jun; Vol. 33 (18), pp. 4752-61. Date of Electronic Publication: 2012 Apr 01.
Publication Year :
2012

Abstract

Colorectal cancer is a significant source of morbidity and mortality in the United States and other Western countries. Oral delivery of therapeutics remains the most patient accepted form of medication. The development of an oral delivery formulation for local delivery of chemotherapeutics in the gastrointestinal tract can potentially alleviate the adverse side effects including systemic cytotoxicity, as well as focus therapy to the lesions. Here we develop an oral formulation of the chemotherapeutic drug oxaliplatin for the treatment of colorectal cancer. Oxaliplatin was encapsulated in pH sensitive, mucoadhesive chitosan-coated alginate microspheres. The microparticles were formulated to release the chemotherapeutics after passing through the acidic gastric environment thus targeting the intestinal tract. In vivo, these particles substantially reduced the tumor burden in an orthotopic mouse model of colorectal cancer, and reduced mortality.<br /> (Copyright © 2012. Published by Elsevier Ltd.)

Details

Language :
English
ISSN :
1878-5905
Volume :
33
Issue :
18
Database :
MEDLINE
Journal :
Biomaterials
Publication Type :
Academic Journal
Accession number :
22472433
Full Text :
https://doi.org/10.1016/j.biomaterials.2012.03.023