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Maturation of digestive function is retarded and plasma antioxidant capacity lowered in fully weaned low birth weight piglets.
- Source :
-
The British journal of nutrition [Br J Nutr] 2013 Jan 14; Vol. 109 (1), pp. 65-75. Date of Electronic Publication: 2012 Apr 03. - Publication Year :
- 2013
-
Abstract
- The digestive function of low birth weight (LBW) pigs post-weaning has been poorly studied. Therefore, newborns from eleven hyperprolific sows were weighed, weaned at 27·2 d and fed a starter diet until sampling. Sampling was done between 18 and 28 d post-weaning. An LBW piglet (n 19) was defined as a piglet having a birth weight less than 1 kg and less than the lower quartile of litter birth weights. Normal birth weight (NBW) piglets (n 13) were having a birth weight close to the mean litter birth weight. For each piglet, eighty-eight variables were determined. Data were analysed with linear models with type of piglet and litter as predictors. A principal component analysis was performed to determine the most important discriminating variables. In the LBW pig, the development of the digestive tract post-weaning was delayed: lower small-intestinal weight:length ratio due to a thinner tela submucosa and tunica muscularis and a higher secretory capacity, both in the distal jejunum. These observations might be a consequence of lower circulating insulin-like growth factor-1 (IGF-1) concentrations (126 (se 10·0) v. 158 (se 12·0) ng/ml for LBW and NBW, respectively) and a lower density of IGF-1 receptors in the proximal small intestine. Additionally, the plasma antioxidant capacity was lower for the LBW pig. Taken together, in the LBW piglet, the normal gut maturation post-weaning was retarded and this did not seem to be related to the weaning transition as such.
- Subjects :
- Animals
Birth Weight
Crosses, Genetic
Fetal Growth Retardation metabolism
Fetal Growth Retardation pathology
Fetal Growth Retardation physiopathology
Gastrointestinal Contents chemistry
Hydrogen-Ion Concentration
Insulin-Like Growth Factor I analysis
Intestinal Mucosa metabolism
Intestinal Mucosa pathology
Intestinal Mucosa physiopathology
Intestine, Small metabolism
Intestine, Small pathology
Organ Size
Principal Component Analysis
Receptor, IGF Type 1 metabolism
Sus scrofa
Swine
Swine Diseases metabolism
Swine Diseases pathology
Weaning
Weight Gain
Antioxidants analysis
Digestion
Down-Regulation
Fetal Growth Retardation veterinary
Intestine, Small physiopathology
Swine Diseases blood
Swine Diseases physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 109
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 22470197
- Full Text :
- https://doi.org/10.1017/S0007114512000670