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Serotonin transporter gene polymorphisms: a case-control study.
- Source :
-
Brazilian dental journal [Braz Dent J] 2012; Vol. 23 (1), pp. 68-71. - Publication Year :
- 2012
-
Abstract
- Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter, are involved in alcoholism and tobacco use and are influenced by polymorphism of the promoter region of 5HTT (5-HTTLPR). As alcohol and tobacco consumption have been implicated in the pathogenesis of oral cancer, the purpose of this study was to investigate 5-HTTLPR polymorphism in patients with oral squamous cell carcinoma (OSCC) compared with a control group in a sample of Brazilian patients. One hundred and three patients affected by OSCC and 103 volunteers without OSCC were genotyped for 5-HTTLPR. Both groups were matched for age, sex and tobacco use. The chi-squared test was used for statistical analysis (α=0.05). There was no statistically significant difference in 5-HTTLPR genotypes between case and control group (p= 0.408). In conclusion, the present investigation demonstrated that serotonin transporter polymorphisms are not implicated in the OSSC development.
- Subjects :
- Adult
Aged
Aged, 80 and over
Brazil
Case-Control Studies
Chi-Square Distribution
Female
Genotype
Humans
Male
Middle Aged
Mouth Neoplasms etiology
Polymerase Chain Reaction
Promoter Regions, Genetic
Alcoholism genetics
Mouth Neoplasms genetics
Polymorphism, Genetic
Serotonin Plasma Membrane Transport Proteins genetics
Smoking genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1806-4760
- Volume :
- 23
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Brazilian dental journal
- Publication Type :
- Academic Journal
- Accession number :
- 22460318
- Full Text :
- https://doi.org/10.1590/s0103-64402012000100012