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Double-stranded oligonucleotides containing 5-aminomethyl-2'-deoxyuridine form thermostable anti-parallel triplexes with single-stranded DNA or RNA.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Apr 15; Vol. 22 (8), pp. 2681-3. Date of Electronic Publication: 2012 Mar 14. - Publication Year :
- 2012
-
Abstract
- This Letter describes the synthesis and properties of double-stranded antisense oligonucleotides connected with a pentaerythritol linker. We found that double-stranded antisense oligonucleotides with aminomethyl residues have high affinity for single-stranded DNA or RNA in buffer solutions with and without MgCl(2). Thus, these oligonucleotides would be useful as antisense oligonucleotides for targeting single-stranded RNA through triplex formation.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- DNA chemistry
DNA, Single-Stranded drug effects
Drug Delivery Systems
Drug Stability
Hydrogen Bonding
Hydrogen-Ion Concentration
Magnesium Chloride chemistry
Oligoribonucleotides, Antisense pharmacology
RNA drug effects
Temperature
Thymidine chemistry
DNA, Single-Stranded chemistry
Oligoribonucleotides, Antisense chemistry
RNA chemistry
Thymidine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 22460027
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.03.024