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The flow-metabolic phenotype of primary colorectal cancer: assessment by integrated 18F-FDG PET/perfusion CT with histopathologic correlation.
- Source :
-
Journal of nuclear medicine : official publication, Society of Nuclear Medicine [J Nucl Med] 2012 May; Vol. 53 (5), pp. 687-92. Date of Electronic Publication: 2012 Mar 27. - Publication Year :
- 2012
-
Abstract
- Unlabelled: The aim of this study was to assess the in vivo flow-metabolic phenotype in primary colorectal cancer with integrated (18)F-FDG PET/perfusion CT and its relationship to gold standard histopathologic assessment of angiogenesis and hypoxia.<br />Methods: 45 patients (26 male and 19 female; mean age, 67.6 y) with primary colorectal cancer underwent integrated (18)F-FDG PET/perfusion CT, deriving tumor glucose metabolism (maximum standardized uptake value) and regional blood flow. From this cohort, 35 underwent surgery subsequently, without intervening neoadjuvant treatment, allowing histopathologic correlation with tumor stage, CD105 microvessel density, vascular endothelial growth factor (VEGF), glucose transporter protein 1 (Glut-1), and hypoxia-inducible factor 1 expression.<br />Results: The flow-metabolic ratio was significantly lower for tumors with higher VEGF (3.65 vs. 5.98; P = 0.01) or hypoxia-inducible factor 1 expression (3.63 vs. 5.48; P = 0.04) versus tumors with lower expression. There were significant negative correlations between the tumor flow-metabolic ratio and VEGF expression (r = -0.55, P = 0.0008), indicating that tumors with low blood flow but higher metabolism were associated with higher VEGF expression. Flow and metabolism were coupled in higher-stage (stage III/IV) tumors but not lower-stage tumors (stage I/II) (r = 0.47, P = 0.03, vs. r = 0.09, P = 0.65, respectively.<br />Conclusion: Tumors with a low-flow-high-metabolism phenotype demonstrated higher VEGF expression and may reflect a more angiogenic phenotype.
- Subjects :
- Aged
Aged, 80 and over
Cell Hypoxia
Colorectal Neoplasms metabolism
Colorectal Neoplasms pathology
Female
Humans
Male
Middle Aged
Neovascularization, Pathologic diagnostic imaging
Neovascularization, Pathologic pathology
Colorectal Neoplasms diagnostic imaging
Colorectal Neoplasms physiopathology
Fluorodeoxyglucose F18
Multimodal Imaging
Perfusion Imaging
Phenotype
Positron-Emission Tomography
Regional Blood Flow
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1535-5667
- Volume :
- 53
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of nuclear medicine : official publication, Society of Nuclear Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22454485
- Full Text :
- https://doi.org/10.2967/jnumed.111.098525