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Effect of angiotensin-converting enzyme inhibitor quadropril on dynamic parameters of vascular tone under conditions of NO synthesis blockade in normotensive and spontaneously hypertensive rats.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 Jul; Vol. 151 (3), pp. 311-3. - Publication Year :
- 2011
-
Abstract
- The role of NO in the mechanism of quadropril modulation of the flow-dependent vasodilation was examined in normotensive (Wistar) and spontaneously hypertensive (SHR) rats. The abdominal aorta was cannulated and autoperfused at different volume rates to obtain the pressure-flow curves. In the first experimental series, the blood flow-pressure dependence was measured before and after intravenous injection of quadropril (1 mg/kg). In the next series, this dependence was obtained before and after injection of NO-synthase inhibitor L-NNA (10 mg/kg) and quadropril, respectively. Quadropril potentiated vasodilation caused by an increase in perfusion volume rate in both normo- and hypertensive rats and stabilized intravascular pressure. Inhibition of NO synthesis elevated hydraulic resistance and decreased stability of intravascular pressure in normo- and hypertensive rats. In normotensive rats, these changes were promoted by a decrease in vascular distensibility. Under these conditions, quadropril pronouncedly potentiated the flow-dependent vasodilation only in SHR rats, which was revealed methodically by an increase in perfusion rate in the posterior quarter of the body. Thus, in SHR rats the quadropril-potentiated vasodilation in response to increased perfusion rate does not depend on NO synthesis.
- Subjects :
- Animals
Blood Flow Velocity drug effects
Blood Pressure drug effects
Enalapril pharmacology
Hypertension enzymology
Male
Nitric Oxide biosynthesis
Rats
Rats, Inbred SHR
Rats, Wistar
Vascular Resistance drug effects
omega-N-Methylarginine pharmacology
Angiotensin-Converting Enzyme Inhibitors pharmacology
Enalapril analogs & derivatives
Hemodynamics drug effects
Hypertension physiopathology
Nitric Oxide metabolism
Vasodilation drug effects
Subjects
Details
- Language :
- English; Russian
- ISSN :
- 1573-8221
- Volume :
- 151
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22451874
- Full Text :
- https://doi.org/10.1007/s10517-011-1317-9