Back to Search
Start Over
Hemophagocytic lymphohistiocytosis in a rheumatoid arthritis patient treated with infliximab.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2012; Vol. 51 (6), pp. 655-7. Date of Electronic Publication: 2012 Mar 15. - Publication Year :
- 2012
-
Abstract
- Hemophagocytic lymphohistiocytosis (HLH) is a rare condition with high mortality. We report a case of a 74-year-old woman with rheumatoid arthritis who developed HLH secondary to pyelonephritis due to Escherichia coli infection following infliximab treatment. Bone marrow aspiration showed proliferation of histiocytes with hemophagocytosis. The patient died despite treatment with intravenous antibiotics intravenous methylprednisolone and intravenous immunoglobulin. Cytokine levels were measured and are discussed.
- Subjects :
- Aged
Anti-Bacterial Agents therapeutic use
Antibodies, Monoclonal therapeutic use
Antirheumatic Agents therapeutic use
Arthritis, Rheumatoid drug therapy
Arthritis, Rheumatoid immunology
Bone Marrow pathology
Escherichia coli Infections drug therapy
Fatal Outcome
Female
Histiocytes pathology
Humans
Immunocompromised Host
Immunoglobulins, Intravenous therapeutic use
Immunosuppressive Agents therapeutic use
Infliximab
Meropenem
Methylprednisolone therapeutic use
Pyelonephritis drug therapy
Thienamycins therapeutic use
Antibodies, Monoclonal adverse effects
Antirheumatic Agents adverse effects
Arthritis, Rheumatoid complications
Escherichia coli Infections complications
Immunosuppressive Agents adverse effects
Lymphohistiocytosis, Hemophagocytic etiology
Pyelonephritis complications
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 51
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 22449679
- Full Text :
- https://doi.org/10.2169/internalmedicine.51.5687