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Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH.
- Source :
-
BMC gastroenterology [BMC Gastroenterol] 2012 Mar 26; Vol. 12, pp. 25. Date of Electronic Publication: 2012 Mar 26. - Publication Year :
- 2012
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Abstract
- Background: The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.<br />Methods: Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.<br />Results: The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).<br />Conclusions: In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.
- Subjects :
- Adult
Drug Synergism
Gastric Acidity Determination
Gastric Juice chemistry
Humans
Hydrogen-Ion Concentration drug effects
Male
Statistics, Nonparametric
Young Adult
Benzamides pharmacology
Gastric Acid metabolism
Gastrointestinal Agents pharmacology
Morpholines pharmacology
Omeprazole pharmacology
Proton Pump Inhibitors pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-230X
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- BMC gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 22448810
- Full Text :
- https://doi.org/10.1186/1471-230X-12-25