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Air trapping is a major determinant of persistent airway obstruction in asthmatics.
- Source :
-
Respiratory medicine [Respir Med] 2012 Jun; Vol. 106 (6), pp. 786-93. Date of Electronic Publication: 2012 Mar 23. - Publication Year :
- 2012
-
Abstract
- Chronic persistent airway obstruction has been observed in moderate-to-severe asthmatics despite treatment with inhaled corticosteroids. We investigated which airway changes were associated with this obstruction. High-resolution computed tomography (HRCT) was performed at study entry and reexamined at the time of follow-up when the FEV1 reached a maximally constant level after treatment for 1 year or more with inhaled corticosteroids. Bronchial wall area and air trapping extent were compared in the recovered group (n = 18) and the persistent airway obstruction group (n = 14). Bronchial wall area and air trapping of the initial HRCT were similar between the two groups. On follow-up HRCT, air trapping was markedly decreased in the recovered group compared with that on initial HRCT (P = 0.017), whereas bronchial wall area did not change. In the persistent-airway-obstruction group, these two parameters did not change during follow-up. When follow-up HRCT was compared, air trapping was significantly greater in the persistent-airway-obstruction group than in the recovered group (P = 0.003). Difference post-bronchodilator FEV1 value between at initial and 2nd HRCT exam was correlated with difference air trapping value between at initial and 2nd HRCT exam(%) on the follow-up HRCT (P = 0.017). The presence of persistent airflow obstruction were significantly associated with the air trapping % difference between initial and 2nd time (RR = 1.70, P = 0.018). Persistence of AT could be a main contributing factor to chronic persistent airflow obstruction in asthma.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Administration, Inhalation
Aged
Asthma diagnostic imaging
Asthma drug therapy
Asthma physiopathology
Female
Follow-Up Studies
Forced Expiratory Volume physiology
Glucocorticoids administration & dosage
Glucocorticoids therapeutic use
Humans
Male
Middle Aged
Prognosis
Pulmonary Disease, Chronic Obstructive diagnostic imaging
Pulmonary Disease, Chronic Obstructive drug therapy
Pulmonary Disease, Chronic Obstructive physiopathology
Respiratory Function Tests
Tomography, X-Ray Computed methods
Vital Capacity physiology
Asthma complications
Pulmonary Disease, Chronic Obstructive etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-3064
- Volume :
- 106
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Respiratory medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22445772
- Full Text :
- https://doi.org/10.1016/j.rmed.2012.02.012