Back to Search Start Over

Air trapping is a major determinant of persistent airway obstruction in asthmatics.

Authors :
Park SW
Park JS
Jeong SH
Lee YN
Hwangbo Y
Park JS
Lee JH
Jang AS
Kim DJ
Uh ST
Kim YH
Park CS
Source :
Respiratory medicine [Respir Med] 2012 Jun; Vol. 106 (6), pp. 786-93. Date of Electronic Publication: 2012 Mar 23.
Publication Year :
2012

Abstract

Chronic persistent airway obstruction has been observed in moderate-to-severe asthmatics despite treatment with inhaled corticosteroids. We investigated which airway changes were associated with this obstruction. High-resolution computed tomography (HRCT) was performed at study entry and reexamined at the time of follow-up when the FEV1 reached a maximally constant level after treatment for 1 year or more with inhaled corticosteroids. Bronchial wall area and air trapping extent were compared in the recovered group (n = 18) and the persistent airway obstruction group (n = 14). Bronchial wall area and air trapping of the initial HRCT were similar between the two groups. On follow-up HRCT, air trapping was markedly decreased in the recovered group compared with that on initial HRCT (P = 0.017), whereas bronchial wall area did not change. In the persistent-airway-obstruction group, these two parameters did not change during follow-up. When follow-up HRCT was compared, air trapping was significantly greater in the persistent-airway-obstruction group than in the recovered group (P = 0.003). Difference post-bronchodilator FEV1 value between at initial and 2nd HRCT exam was correlated with difference air trapping value between at initial and 2nd HRCT exam(%) on the follow-up HRCT (P = 0.017). The presence of persistent airflow obstruction were significantly associated with the air trapping % difference between initial and 2nd time (RR = 1.70, P = 0.018). Persistence of AT could be a main contributing factor to chronic persistent airflow obstruction in asthma.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1532-3064
Volume :
106
Issue :
6
Database :
MEDLINE
Journal :
Respiratory medicine
Publication Type :
Academic Journal
Accession number :
22445772
Full Text :
https://doi.org/10.1016/j.rmed.2012.02.012