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Verticillosides A-M: Polyoxygenated pregnane glycosides from Asclepias verticillata L.
- Source :
-
Phytochemistry [Phytochemistry] 2012 Jun; Vol. 78, pp. 179-89. Date of Electronic Publication: 2012 Mar 23. - Publication Year :
- 2012
-
Abstract
- As part of our ongoing effort to explore the chemical diversity of plants of the United States Midwest region, the isolation and identification of 13 pregnane glycosides named verticillosides A-M from Asclepias verticillata L. are reported. The structures of these compounds were elucidated by various spectroscopic techniques, including 1D and 2D NMR, IR, UV, and HRMS. The cytotoxicity of the isolates was evaluated against paired breast cell lines Hs578T (cancer) and Hs578Bst (normal), however, no significant growth inhibition was observed.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic chemistry
Antineoplastic Agents, Phytogenic pharmacology
Drug Screening Assays, Antitumor
Glycosides chemistry
Glycosides pharmacology
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pregnanes chemistry
Pregnanes pharmacology
United States
Antineoplastic Agents, Phytogenic isolation & purification
Asclepias chemistry
Glycosides isolation & purification
Pregnanes isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 78
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22445072
- Full Text :
- https://doi.org/10.1016/j.phytochem.2012.02.019