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In vitro effects of anandamide and prostamide e2 on normal and transformed nerve cells.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2011 May; Vol. 151 (1), pp. 30-2. - Publication Year :
- 2011
-
Abstract
- We studied the effects of endocannabinoid anandamide and its cyclooxygenase derivative prostamide E2 on cultured cerebellar granular cells and C6 glioma cells from rats. Prostamide E2 prevented apoptosis in cerebellar neurons induced by potassium deprivation of cultures, while anandamide had no neuroprotective properties. Prostamide E2 did not modulate the survival rate of glioma cells, while anandamide produced a cytotoxic effect. Our results indicate that cyclooxygenase transformation of anandamide is followed by the loss of antitumor activity of this agent. By contrast, prostamide E2 exhibited strong neuroprotective properties.
- Subjects :
- Animals
Apoptosis drug effects
Arachidonic Acids pharmacology
Biotransformation
Cell Survival drug effects
Cells, Cultured
Cerebellum cytology
Cerebellum drug effects
Cerebellum metabolism
Dinoprostone metabolism
Dinoprostone pharmacology
Dose-Response Relationship, Drug
Endocannabinoids
Glioma metabolism
Glioma pathology
Neurons cytology
Neurons metabolism
Neuroprotective Agents metabolism
Polyunsaturated Alkamides pharmacology
Potassium metabolism
Potassium Deficiency metabolism
Primary Cell Culture
Prostaglandin-Endoperoxide Synthases metabolism
Rats
Arachidonic Acids metabolism
Dinoprostone analogs & derivatives
Neurons drug effects
Neuroprotective Agents pharmacology
Polyunsaturated Alkamides metabolism
Potassium pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 151
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 22442796
- Full Text :
- https://doi.org/10.1007/s10517-011-1252-9