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Rapid enrichment of cell phospholipids in long-chain polyunsaturated ω-3 fatty acids after a bolus intravenous injection of a medium-chain triacylglycerol: fish oil emulsion in humans.
- Source :
-
JPEN. Journal of parenteral and enteral nutrition [JPEN J Parenter Enteral Nutr] 2012 Nov; Vol. 36 (6), pp. 671-6. Date of Electronic Publication: 2012 Mar 20. - Publication Year :
- 2012
-
Abstract
- The present review aims at highlighting the use of a recently developed medium-chain triacylglycerol:fish oil (MCT:FO) emulsion for the rapid and sustained enrichment of long-chain polyunsaturated ω-3 fatty acids in cell phospholipids. Preclinical in vitro, in vivo, and ex vivo experiments are briefly considered with emphasis on the changes in the fatty acid pattern of cell phospholipids in several organs, the partial correction of liver steatosis, and the cardiovascular modification of cationic and functional variables observed in ω-3-depleted rats examined 60-120 minutes after a bolus intravenous (IV) injection (1.0 mL) of the MCT:FO emulsion. The clinical findings collected in healthy male volunteers before or after the bolus IV injection (50.0 mL) of either the MCT:FO emulsion or a control medium-chain triacylglycerol:long-chain triacylglycerol emulsion are also reviewed, with emphasis on the rapid (within 60 minutes) and sustained (up to 2-3 days) enrichment of platelet and white blood cell phospholipids in long-chain polyunsaturated ω-3 fatty acids and hemostatic safety of the present procedure proposed as a tool for the rapid prevention or correction of metabolic and functional disturbances in humans with a relative deficiency in such ω-3 fatty acids.
- Subjects :
- Animals
Fat Emulsions, Intravenous metabolism
Fatty Acids, Omega-3 metabolism
Fatty Liver metabolism
Fatty Liver therapy
Fish Oils metabolism
Humans
Injections, Intravenous
Male
Phospholipids blood
Rats
Triglycerides metabolism
Blood Cells metabolism
Fat Emulsions, Intravenous therapeutic use
Fatty Acids, Omega-3 therapeutic use
Fish Oils therapeutic use
Phospholipids metabolism
Triglycerides therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1941-2444
- Volume :
- 36
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- JPEN. Journal of parenteral and enteral nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 22434201
- Full Text :
- https://doi.org/10.1177/0148607112439211