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Subjective and objective assessment of edema during adjuvant chemotherapy for breast cancer using taxane-containing regimens in a randomized controlled trial: The National Surgical Adjuvant Study of Breast Cancer 02.
- Source :
-
Oncology [Oncology] 2012; Vol. 82 (3), pp. 131-8. Date of Electronic Publication: 2012 Mar 15. - Publication Year :
- 2012
-
Abstract
- Objective: To elucidate the time course of taxane-induced edema which may affect the patients' quality of life (QOL).<br />Patients and Methods: Our study included the first 300 Japanese patients assigned to 1 of 4 regimens using docetaxel (DTX) or paclitaxel (PTX) by 1:1:1:1 in a randomized controlled trial to evaluate the efficacy of adjuvant therapies for node-positive breast cancer. Patients' QOL was prospectively assessed by the functional assessment of cancer therapy (FACT)-breast and -taxane (FACT-T) subscale. The scores of FACT items regarding edema and body weight were used as indicators of edema.<br />Results: The scores for 'anasarca', 'edema of the hands' and 'edema of the legs and feet' of the FACT-T subscale worsened up to 1-2 months after chemotherapy, and body weights increased remarkably until cycle 8 in patients treated with DTX alone (75 mg/m(2), 8 cycles, every 3 weeks). Edema-related symptoms and body weight were relatively stable in the other treatment groups. There were statistically significant differences in the scores of those items and in the changes of body weight both between the DTX-alone group and the other three groups combined, and between the groups using DTX and those using PTX.<br />Conclusion: Many patients receiving DTX for >4 cycles suffered significantly from edema.<br /> (Copyright © 2012 S. Karger AG, Basel.)
- Subjects :
- Adult
Aged
Chemotherapy, Adjuvant
Docetaxel
Female
Humans
Middle Aged
Paclitaxel administration & dosage
Prognosis
Prospective Studies
Taxoids administration & dosage
Antineoplastic Combined Chemotherapy Protocols adverse effects
Breast Neoplasms drug therapy
Edema chemically induced
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0232
- Volume :
- 82
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 22433221
- Full Text :
- https://doi.org/10.1159/000336480