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Two new triterpenoid saponins from the husks of Xanthoceras sorbifolia.

Authors :
Li ZL
Li DY
He XM
Hua HM
Source :
Natural product research [Nat Prod Res] 2013; Vol. 27 (3), pp. 232-7. Date of Electronic Publication: 2012 Mar 19.
Publication Year :
2013

Abstract

Two new oleanane triterpenoid saponins, xanthohuskisides A (1) and B (2), were isolated from the husks of Xanthoceras sorbifolia. The structures of these two compounds were established as 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-[α-L-rhamnopyranosyl (1→2)]-β-D-glucopyranosyl 16-deoxybarringtogenol C (1) and 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl 16-deoxybarringtogenol C (2), respectively, based on the analysis on their spectral data including NMR and HR-ESI-MS. The growth inhibitory activities of compounds 1 and 2 were assayed, and 2 showed moderate activity against U937 cell line with the IG(50) value of 82.85 ± 1.58 µM.

Details

Language :
English
ISSN :
1478-6427
Volume :
27
Issue :
3
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
22429027
Full Text :
https://doi.org/10.1080/14786419.2012.671316