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A prospective cohort study of the long-term effects of CPAP on carotid artery intima-media thickness in obstructive sleep apnea syndrome.
- Source :
-
Respiratory research [Respir Res] 2012 Mar 16; Vol. 13, pp. 22. Date of Electronic Publication: 2012 Mar 16. - Publication Year :
- 2012
-
Abstract
- Objective: To examine the long-term effect of CPAP on carotid artery intima-media thickness (IMT) in patients with Obstructive sleep apnea syndrome(OSAS).<br />Methods: A prospective observational study over 12 months at a teaching hospital on 50 patients newly diagnosed with OSAS who received CPAP or conservative treatment (CT). Carotid IMT was assessed with B-mode Doppler ultrasound from both carotid arteries using images of the far wall of the distal 10 mm of the common carotid arteries at baseline, 6 months and 12 months. MEASUREMENTS AND RESULTS [MEAN (SE)]: Altogether 28 and 22 patients received CPAP and CT respectively without significant differences in age 48.8(1.8) vs 50.5(2.0)yrs, BMI 28.2(0.7) vs 28.0(1.2)kg/m2, ESS 13.1(0.7) vs 12.7(0.6), AHI 38(3) vs 39(3)/hr, arousal index 29(2) vs 29(2)/hr, minimum SaO2 75(2) vs 77(2)% and existing co-morbidities. CPAP usage was 4.6(0.3) and 4.7(0.4)hrs/night over 6 months and 1 year respectively. Carotid artery IMT at baseline, 6 months, and 12 months were 758(30), 721(20), and 705(20)micron for the CPAP group versus 760(30), 770(30), and 778(30)micron respectively for the CT group, p = 0.002. Among those free of cardiovascular disease(n = 24), the carotid artery IMT at baseline, 6 months and 12 months were 722(40), 691(40), and 659(30)micron for the CPAP group (n = 12) with usage 4.5(0.7) and 4.7(0.7) hrs/night over 6 months and 12 months whereas the IMT data for the CT group(n = 12) were 660(20), 685(10), and 690(20)micron respectively, p = 0.006.<br />Conclusions: Reduction of carotid artery IMT occurred mostly in the first 6 months and was sustained at 12 months in patients with reasonable CPAP compliance.
- Subjects :
- Alcohol Drinking prevention & control
Cohort Studies
Exercise Therapy
Female
Humans
Longitudinal Studies
Male
Middle Aged
Patient Compliance
Prospective Studies
Sleep Deprivation prevention & control
Time Factors
Weight Loss
Carotid Arteries diagnostic imaging
Carotid Intima-Media Thickness
Continuous Positive Airway Pressure
Sleep Apnea, Obstructive diagnostic imaging
Sleep Apnea, Obstructive therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1465-993X
- Volume :
- 13
- Database :
- MEDLINE
- Journal :
- Respiratory research
- Publication Type :
- Academic Journal
- Accession number :
- 22424053
- Full Text :
- https://doi.org/10.1186/1465-9921-13-22