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Emodin prevents intrahepatic fat accumulation, inflammation and redox status imbalance during diet-induced hepatosteatosis in rats.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2012; Vol. 13 (2), pp. 2276-2289. Date of Electronic Publication: 2012 Feb 20. - Publication Year :
- 2012
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Abstract
- High-fat and/or high-carbohydrate diets may predispose to several metabolic disturbances including liver fatty infiltration (hepatosteatosis) or be associated with necro-inflammation and fibrosis (steatohepatitis). Several studies have emphasized the hepatoprotective effect of some natural agents. In this study, we investigated the potential therapeutic effects of the treatment with emodin, an anthraquinone derivative with anti-oxidant and anti-cancer abilities, in rats developing diet-induced hepatosteatosis and steatohepatitis. Sprague-Dawley rats were fed a standard diet (SD) for 15 weeks, or a high-fat/high-fructose diet (HFD/HF). After 5 weeks, emodin was added to the drinking water of some of the SD and HFD/HF rats. The experiment ended after an additional 10 weeks. Emodin-treated HFD/HF rats were protected from hepatosteatosis and metabolic derangements usually observed in HFD/HF animals. Furthermore, emodin exerted anti-inflammatory activity by inhibiting the HFD/HF-induced increase of tumor necrosis factor (TNF)-α. Emodin also affected the hepatocytes glutathione homeostasis and levels of the HFD/HF-induced increase of glutathionylated/phosphorylated phosphatase and tensin homolog (PTEN). In conclusion, we demonstrated that a natural agent such as emodin can prevent hepatosteatosis, preserving liver from pro-inflammatory and pro-oxidant damage caused by HFD/HF diet. These findings are promising, proposing emodin as a possible hindrance to progression of hepatosteatosis into steatohepatitis.
- Subjects :
- Animals
Cell Survival drug effects
Diet, High-Fat adverse effects
Liver metabolism
Liver pathology
Male
Oxidation-Reduction drug effects
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species metabolism
Emodin pharmacology
Fatty Liver prevention & control
Inflammation prevention & control
Lipid Metabolism drug effects
Liver drug effects
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 22408453
- Full Text :
- https://doi.org/10.3390/ijms13022276