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The first stereoselective total synthesis of (Z)-cryptomoscatone D2, a natural G₂ checkpoint inhibitor.
The first stereoselective total synthesis of (Z)-cryptomoscatone D2, a natural G₂ checkpoint inhibitor.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2012 Apr 01; Vol. 22 (7), pp. 2415-7. Date of Electronic Publication: 2012 Feb 17. - Publication Year :
- 2012
-
Abstract
- The first stereoselective synthesis of (Z)-cryptomoscatone D2, a naturally occurring G(2) checkpoint inhibitor, was accomplished using propane-1,3-diol as the starting material. The Maruoka asymmetric allylation, ring closing metathesis and the hydrogenation of the triple bond employing Lindlar's catalyst were involved as the key steps.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic pharmacology
Catalysis
Cell Line, Tumor
Cryptocarya chemistry
G2 Phase Cell Cycle Checkpoints drug effects
Humans
Hydrogenation
Lactones pharmacology
Molecular Structure
Stereoisomerism
Antineoplastic Agents, Phytogenic chemical synthesis
Lactones chemical synthesis
Propylene Glycols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 22
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 22405831
- Full Text :
- https://doi.org/10.1016/j.bmcl.2012.02.025