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Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma.
- Source :
-
Eye (London, England) [Eye (Lond)] 2012 Jun; Vol. 26 (6), pp. 862-5. Date of Electronic Publication: 2012 Mar 09. - Publication Year :
- 2012
-
Abstract
- Purpose: To describe the histological findings of birdshot chorioretinopathy. DESIGN/PARTICIPANT: This is a case study of a single patient who has both birdshot chorioretinopathy and ciliochoroidal melanoma.<br />Methods: A 55-year-old woman who was HLA-A29 positive and had birdshot chorioretinopathy had a large ciliochoroidal melanoma (T4b N0 M0) and underwent enucleation.<br />Outcome Measures: Using histopathology, we hope to further define the pathological findings in an eye with both birdshot chorioretinopathy and coexistant ciliochoroidal melanomas.<br />Results: The eye showed a ciliochoroidal melanoma. In addition, elsewhere, there were multiple choroidal nodules of lymphocytes that showed the presence of CD3-positive cells, which also stained for CD4 or CD8. There were only a few CD20-positive B cells and rare CD68-positive histiocytes. No granulomas were present.<br />Discussion: To our knowledge, there are only two previous reports describing the histological findings in birdshot chorioretinopathy: one that was HLA-A29 negative showing choroidal granulomas and another that was HLA-A29 positive exhibiting histological findings similar to our case. Incidentally, the latter case had a history of cutaneous melanoma.<br />Conclusion: Birdshot chorioretinopathy is a nongranulomatous nodular infiltration of the choroid.
- Subjects :
- Birdshot Chorioretinopathy
Chorioretinitis complications
Chorioretinitis immunology
Choroid Neoplasms complications
Coloring Agents
Eye Enucleation
Female
Fluorescein Angiography
HLA-A Antigens immunology
Humans
Indocyanine Green
Melanoma complications
Middle Aged
Visual Acuity
Chorioretinitis pathology
Choroid Neoplasms pathology
Melanoma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1476-5454
- Volume :
- 26
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Eye (London, England)
- Publication Type :
- Academic Journal
- Accession number :
- 22402699
- Full Text :
- https://doi.org/10.1038/eye.2012.10