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Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals.
- Source :
-
Virology [Virology] 2012 Jun 05; Vol. 427 (2), pp. 198-207. Date of Electronic Publication: 2012 Mar 07. - Publication Year :
- 2012
-
Abstract
- The recent analysis of the first successful RV144 vaccine trial revealed that a high titer of plasma anti-V2 antibodies (Abs) correlated with a decreased risk of HIV-1 infection in vaccine recipients. To understand the mechanism of immune correlates, we studied seven anti-V2 monoclonal Abs (mAbs) developed from HIV-1 infected individuals. The V2 mAbs target conserved epitopes, including the binding site for α4β7 integrin, and are broadly cross-reactive with various gp120 proteins. Preferential usage of the VH1-69 gene by V2 mAbs may depend on selection by the same antigenic structure. Six of seven V2 mAbs weakly neutralized four to eight of the 41 pseudoviruses tested and resistance to neutralization was correlated with longer V2 domains. The data suggest the presence of shared, conserved structural elements in the V2 loop, and these can be used in the design of vaccine immunogens inducing broadly reactive Abs with anti-viral activities.<br /> (Copyright © 2012 Elsevier Inc. All rights reserved.)
- Subjects :
- Amino Acid Sequence
Antibody Specificity
Antigens, Viral
Epitopes
HIV Antibodies
HIV Infections immunology
HIV Infections virology
Humans
Models, Molecular
Molecular Sequence Data
Protein Conformation
AIDS Vaccines immunology
Antibodies, Monoclonal immunology
HIV Infections prevention & control
HIV-1 immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0341
- Volume :
- 427
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Virology
- Publication Type :
- Academic Journal
- Accession number :
- 22402248
- Full Text :
- https://doi.org/10.1016/j.virol.2012.02.003