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An asymmetric synthesis of L-pyrrolysine.
- Source :
-
Organic letters [Org Lett] 2012 Mar 16; Vol. 14 (6), pp. 1378-81. Date of Electronic Publication: 2012 Mar 06. - Publication Year :
- 2012
-
Abstract
- An efficient asymmetric synthesis of the 22nd amino acid L-pyrrolysine has been accomplished. The key stereogenic centers were installed by an asymmetric conjugate addition reaction. A Staudinger/aza-Wittig cyclization was used to form the acid-sensitive pyrroline ring. Pyrrolysine was synthesized in 13 steps in 20% overall yield.
Details
- Language :
- English
- ISSN :
- 1523-7052
- Volume :
- 14
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Organic letters
- Publication Type :
- Academic Journal
- Accession number :
- 22394273
- Full Text :
- https://doi.org/10.1021/ol300045c