[The expression of GABA(A) receptor alpha1 and GABA(B) receptor 1 in medulla oblongata solitary nucleus and ambiguous nucleus in the cases of tramadol intoxication].

Authors :: Zhang S
Guan DW
Wang L
Wang HX
Zhang GH
Zhao R
Fan YY
Source :: Fa yi xue za zhi [Fa Yi Xue Za Zhi] 2011 Dec; Vol. 27 (6), pp. 401-4.
Publication Year :: 2011
Abstract: Objective: To observe the expression of GABA(A) receptor alpha1 (GABA(A)alpha1) and GABA(B) receptor 1 (GABA(B)1) in human medulla oblongata solitary nucleus and ambiguous nucleus due to tramadol-induced death.<br />Methods: GABA(A)alpha1 and GABA(B)1 were detected by immunohistochemical SP method in tramadol-induced death group and control group. All results were evaluated by images analysis system.<br />Results: Low expression of GABA(A)alpha1 and GABA(B)1 were detected in solitary nucleus and ambiguous nucleus in the control brain tissue. In cases of tramadol-induced death, the expression of GABA(A)alpha1 and GABA(B)1 significantly increased.<br />Conclusion: The mechanism of tramadol intoxication death could be caused by respiratory depression induced by over-expression of GABA(A)alpha1 and GABA(B)1 in medulla oblongata solitary nucleus and ambiguous nucleus.

Subjects :: Adult
Analgesics, Opioid metabolism
Autopsy
Case-Control Studies
Cause of Death
Female
Humans
Immunohistochemistry
Male
Respiration Disorders etiology
Solitary Nucleus metabolism
Staining and Labeling
Tramadol metabolism
Analgesics, Opioid poisoning
Forensic Toxicology
Medulla Oblongata metabolism
Receptors, GABA-A metabolism
Receptors, GABA-B metabolism
Tramadol poisoning

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