Febrile infection-related epilepsy syndrome is not caused by SCN1A mutations.

Authors :: Carranza Rojo D
Harvey AS
Iona X
Dibbens LM
Damiano JA
Arsov T
Gill D
Freeman JL
Leventer RJ
Vincent A
Berkovic SF
McMahon JM
Scheffer IE
Source :: Epilepsy research [Epilepsy Res] 2012 Jun; Vol. 100 (1-2), pp. 194-8. Date of Electronic Publication: 2012 Mar 03.
Publication Year :: 2012
Abstract: Two distinctive epileptic encephalopathies, febrile infection-related epilepsy syndrome (FIRES) and Dravet syndrome (DS), present with febrile status epilepticus in a normal child followed by refractory focal seizures and cognitive decline although there are differentiating features. Abnormalities of the sodium channel gene SCN1A are found in 75% of DS patients. We found no SCN1A mutations or copy number variants in 10 patients with FIRES. Other genetic etiologies deserve consideration.<br /> (Copyright © 2012. Published by Elsevier B.V.)