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Neuroendocrine signalling: natural variations on a Ca2+ theme.

Authors :
Toescu EC
Dayanithi G
Source :
Cell calcium [Cell Calcium] 2012 Mar-Apr; Vol. 51 (3-4), pp. 207-11. Date of Electronic Publication: 2012 Mar 03.
Publication Year :
2012

Abstract

This special issue on Ca(2+) signalling in neuroendocrine cells is an opportunity to assess, through a range of first-class review articles, the complex world of endocrine signalling, a complexity that is probably best captured by calling it "diversity in unity". The unity comes from the fact that all the endocrine cells are excitable cells, able to generate action potentials and are using Ca(2+) as an essential informational molecule, coupling cell stimulation with the activation of secretion, through the exocytotic process. The 'diversity' element, illustrated by almost all the reviews, stems from the modalities employed to achieve the increase in cytosolic Ca(2+) signal, the balance between the participation of Ca(2+) entry through the plasma membrane voltage-operated Ca(2+) channels and the release of Ca(2+) from intracellular Ca(2+) stores, and the cross-talk between the Ca(2+) and cyclic AMP signalling pathways.<br /> (Copyright © 2012. Published by Elsevier India Pvt Ltd.)

Details

Language :
English
ISSN :
1532-1991
Volume :
51
Issue :
3-4
Database :
MEDLINE
Journal :
Cell calcium
Publication Type :
Academic Journal
Accession number :
22385835
Full Text :
https://doi.org/10.1016/j.ceca.2012.01.010