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[Measurement of bronchoconstrictive eicosanoids in chronic obstructive pulmonary disease].
- Source :
-
Pneumonologia i alergologia polska [Pneumonol Alergol Pol] 2012; Vol. 80 (2), pp. 120-6. - Publication Year :
- 2012
-
Abstract
- Introduction: The aim of the study was the evaluation of the concentration of 9α11β prostaglandin F(2) - a stable metabolite of prostaglandin D(2) (PGD(2)) and leukotriene E(4) (LTE(4)) in stable and exacerbated COPD patients.<br />Material and Methods: 29 COPD patients aged 73 ± 8.34, mean FEV1 = 48.64 ± 15.75% of predictive value and 29 healthy controls aged 57.48 ± 10.86, mean FEV1 = 97.17 ± 13.81% of predictive value participated in this study. Samples of urine and blood were taken from COPD patients during exacerbation and in stable state of the disease; LTE(4) was determined in urine using commercial enzyme immunoassay (EIA) and 9α11β prostaglandin F(2) (9α11βPGF(2)) - stable metabolite of PGD(2) was evaluated in blood and urine using GC/MS.<br />Results: LTE(4) concentration in urine (677.15 vs. 436.4 pg/mg of creatinine; p = 0.035) and 9α11βPGF(2) in blood serum (5.35 vs. 3.07 pg/ml; p = 0.007) were significantly higher in exacerbated COPD patients than in control group. There was no difference in LTE(4) level in urine and 9α11βPGF2 in blood serum between exacerbated and stable COPD. The urinary 9α11βPGF(2) concentration did not differ between all studied groups. We found a positive correlation between smoking history and the urine LTE(4) level (r = 0.395; p = 0.002) as well as blood 9α11βPGF(2) concentration (r = 0.603; p = 0.001) in COPD patients.<br />Conclusions: 9α11βPGF(2) and LTE(4) level in urine did not differ between the stable COPD group and the control group. We also did not find any difference between LTE4 level in urine and 9α11βPGF(2) in blood and urine between exacerbated and stable COPD. Finally, LTE(4) concentration in urine and 9α11βPGF(2) in blood occurred to be significantly higher in exacerbated COPD patients than in control group.
- Subjects :
- Aged
Aged, 80 and over
Case-Control Studies
Female
Humans
Male
Middle Aged
Reference Values
Reproducibility of Results
Respiratory Function Tests
Risk Factors
Severity of Illness Index
Vital Capacity
Bronchoconstriction physiology
Leukotriene E4 blood
Leukotriene E4 urine
Prostaglandin D2 blood
Prostaglandin D2 urine
Pulmonary Disease, Chronic Obstructive metabolism
Subjects
Details
- Language :
- Polish
- ISSN :
- 0867-7077
- Volume :
- 80
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Pneumonologia i alergologia polska
- Publication Type :
- Academic Journal
- Accession number :
- 22370980