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Successful treatment with pulse cyclophosphamide of a steroid-refractory hepatitic variant of liver acute graft-vs.-host disease in a child.
- Source :
-
Pediatric transplantation [Pediatr Transplant] 2012 Nov; Vol. 16 (7), pp. E315-9. Date of Electronic Publication: 2012 Feb 26. - Publication Year :
- 2012
-
Abstract
- A 13-yr-old boy with recurrent acute myeloid leukemia underwent HSCT using cells from an unrelated donor who matched all HLA antigens except one. Forty-two days later, the patient developed a steroid-refractory hepatitic variant of liver GVHD with peak ALT and T.Bil values of 1406 mU/mL and 10.4 mg/dL, respectively. He was successfully treated with pulse Cy (1000 mg/dose × one day) without a change in chimerism being observed or acquiring an infection. All immunosuppressant therapies could be discontinued 12 months after HSCT. Two yr after HSCT, the patient remains in CR without chronic GVHD. This single case report suggests that pulse Cy may be a promising therapy for steroid-refractory GVHD, especially hepatitic GVHD, but needs to be further tested in clinical trials.<br /> (© 2012 John Wiley & Sons A/S.)
- Subjects :
- Adolescent
Drug Resistance
Hematopoietic Stem Cell Transplantation adverse effects
Humans
Immunosuppressive Agents therapeutic use
Leukemia, Myeloid, Acute complications
Leukemia, Myeloid, Acute therapy
Male
Time Factors
Transplantation Conditioning adverse effects
Transplantation, Homologous
Treatment Outcome
Cyclophosphamide administration & dosage
Graft vs Host Disease therapy
Hepatitis drug therapy
Liver Failure therapy
Liver Failure virology
Steroids adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1399-3046
- Volume :
- 16
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Pediatric transplantation
- Publication Type :
- Academic Journal
- Accession number :
- 22364121
- Full Text :
- https://doi.org/10.1111/j.1399-3046.2012.01664.x