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Management of autoimmune diseases after haematopoietic stem cell transplantation.
- Source :
-
British journal of haematology [Br J Haematol] 2012 May; Vol. 157 (3), pp. 281-90. Date of Electronic Publication: 2012 Feb 24. - Publication Year :
- 2012
-
Abstract
- Autologous and allogeneic haematopoietic stem cell transplantation (HSCT) is an option for the treatment of malignant and non-malignant diseases, including the severe autoimmune diseases. Intriguingly, the 'new' autoimmunity developing after transplantation is a constantly recognized phenomenon, which has to be differentiated from original disease relapse, toxicity, infection and graft-versus-host disease. The reported autoimmune diseases occurring in this setting are mainly antibody-associated and organ-specific, with scarce evidence in support for specific treatment options. This review focuses on current concepts on the pathogenesis, the available data on incidence, risk factors, manifestations and treatment of post-HSCT autoimmune diseases.<br /> (© 2012 Blackwell Publishing Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2141
- Volume :
- 157
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 22360687
- Full Text :
- https://doi.org/10.1111/j.1365-2141.2012.09070.x