Back to Search Start Over

Gene therapy for ischemic heart disease: review of clinical trials.

Authors :
Eibel B
Rodrigues CG
Giusti II
Nesralla IA
Prates PR
Sant'Anna RT
Nardi NB
Kalil RA
Source :
Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular [Rev Bras Cir Cardiovasc] 2011 Oct-Dec; Vol. 26 (4), pp. 635-46.
Publication Year :
2011

Abstract

Severe ischemic heart disease with refractory angina, occurs in increasing incidence. Alternative forms of treatment, in an attempt to reduce myocardial ischemia and relief of symptoms has been studied. In this context, gene therapy is an option, for the possibility of inducing angiogenesis, establish collateral circulation and reperfuse ischemic myocardium. Several clinical trials have been conducted and, except for specific cases of adverse effects, there is indication of safety, feasibility and potential effectiveness of therapy. The clinical benefit, however, is not yet well established. In this article we review the clinical trials of gene therapy for patients with ischemic heart disease. The approach includes: (1) myocardial ischemia and angiogenesis on the pathophysiological aspects involved, (2) growth factors, dealing with specific aspects and justifying the use in cardiac patients with no option for conventional therapy, (3) controlled clinical trials, where a summary of the main studies involving gene therapy for severe ischemic heart disease is presented, (4) our experience, especially on preliminary results of the first gene therapy clinical trial in Brazil and (5) future prospects.

Details

Language :
English; Portuguese
Volume :
26
Issue :
4
Database :
MEDLINE
Journal :
Revista brasileira de cirurgia cardiovascular : orgao oficial da Sociedade Brasileira de Cirurgia Cardiovascular
Publication Type :
Academic Journal
Accession number :
22358281
Full Text :
https://doi.org/10.5935/1678-9741.20110056