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IgA antibodies against β2 glycoprotein I in hemodialysis patients are an independent risk factor for mortality.
- Source :
-
Kidney international [Kidney Int] 2012 Jun; Vol. 81 (12), pp. 1239-44. Date of Electronic Publication: 2012 Feb 22. - Publication Year :
- 2012
-
Abstract
- Cardiovascular complications are the most important cause of death in patients on dialysis with end-stage renal disease. Antibodies reacting with β-glycoprotein I seem to play a pathogenic role in antiphospholipid syndrome and stroke and are involved in the origin of atherosclerosis. Here we evaluated the presence of anticardiolipin and anti-β-glycoprotein I antibodies together with other vascular risk factors and their relationship with mortality and cardiovascular morbidity in a cohort of 124 hemodialysis patients prospectively followed for 2 years. Of these, 41 patients were significantly positive for IgA anti-β-glycoprotein I, and the remaining had normal values. At 24 months, overall and cardiovascular mortality and thrombotic events were all significantly higher in patients with high anti-β-glycoprotein I antibodies. Multivariate analysis using Cox regression modeling found that age, hypoalbuminemia, use of dialysis catheters, and IgA β-glycoprotein I antibodies were independent risk factors for death. Thus, IgA antibodies to β-glycoprotein I are detrimental to the clinical outcome of hemodialysis patients.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antibodies, Anticardiolipin blood
Cardiovascular Diseases blood
Cardiovascular Diseases immunology
Chi-Square Distribution
Female
Humans
Kaplan-Meier Estimate
Kidney Failure, Chronic blood
Kidney Failure, Chronic immunology
Kidney Failure, Chronic mortality
Male
Middle Aged
Multivariate Analysis
Proportional Hazards Models
Prospective Studies
Renal Dialysis adverse effects
Risk Assessment
Risk Factors
Spain
Time Factors
Treatment Outcome
Young Adult
Autoantibodies blood
Cardiovascular Diseases mortality
Immunoglobulin A blood
Kidney Failure, Chronic therapy
Renal Dialysis mortality
beta 2-Glycoprotein I immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 81
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 22358146
- Full Text :
- https://doi.org/10.1038/ki.2011.477