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Characterization of a novel lytic protein encoded by the Bacillus cereus E33L gene ampD as a Bacillus anthracis antimicrobial protein.
- Source :
-
Applied and environmental microbiology [Appl Environ Microbiol] 2012 Apr; Vol. 78 (8), pp. 3025-7. Date of Electronic Publication: 2012 Feb 17. - Publication Year :
- 2012
-
Abstract
- Lytic proteins encoded by bacterial genomes have been implicated in cell wall biosynthesis and recycling. The Bacillus cereus E33L ampD gene encodes a putative N-acetylmuramoyl-l-alanine amidase. This gene, expressed in vitro, produced a very stable, highly active lytic protein. Very low concentrations rapidly and efficiently lyse vegetative Bacillus anthracis cells.
- Subjects :
- Anti-Infective Agents chemistry
Anti-Infective Agents metabolism
Bacillus anthracis cytology
Bacterial Proteins chemistry
Colony Count, Microbial
Enzyme Stability
Microbial Viability drug effects
Microscopy
N-Acetylmuramoyl-L-alanine Amidase chemistry
Protein Stability
Bacillus anthracis drug effects
Bacillus anthracis physiology
Bacillus cereus enzymology
Bacillus cereus genetics
Bacterial Proteins genetics
Bacterial Proteins metabolism
Bacteriolysis
N-Acetylmuramoyl-L-alanine Amidase genetics
N-Acetylmuramoyl-L-alanine Amidase metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1098-5336
- Volume :
- 78
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Applied and environmental microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 22344637
- Full Text :
- https://doi.org/10.1128/AEM.06906-11