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High prevalence of primary biliary cirrhosis and disease-associated autoantibodies in Japanese patients with systemic sclerosis.
- Source :
-
Modern rheumatology [Mod Rheumatol] 2012 Nov; Vol. 22 (6), pp. 892-8. Date of Electronic Publication: 2012 Feb 12. - Publication Year :
- 2012
-
Abstract
- Objective: To investigate the prevalence of primary biliary cirrhosis (PBC) and PBC-associated autoantibodies in Japanese systemic sclerosis (SSc) patients.<br />Methods: Clinical data from 225 Japanese SSc patients were retrospectively obtained. Serum samples from these patients were examined for PBC-associated autoantibodies, anti-mitochondrial M2 antibodies (AMA), anti-sp100 antibodies (anti-sp100), and anti-gp210 antibodies (anti-gp210) by enzyme-linked immunosorbent assay.<br />Results: Of 225 patients, 37 (16.4%) had AMA, 13 (5.8%) had anti-sp100, and 3 (1.3%) had anti-gp210. Three patients were positive for both AMA and anti-sp100, and 2 were positive for both AMA and anti-gp210. PBC was found in 22 (9.8%) patients positive for AMA with or without anti-sp100 or anti-gp210, but not in those with anti-sp100 or anti-gp210 without AMA. Furthermore, 13 patients lacking these three antibodies were diagnosed with or suspected of PBC by liver biopsy and/or their clinical manifestation. Multivariable analysis revealed that AMA and anti-centromere antibodies were independently associated with PBC in SSc patients, while anti-sp100 and anti-gp210 were not.<br />Conclusions: This study has demonstrated even higher prevalence of both PBC-associated autoantibodies and PBC in the Japanese SSc population than in the Caucasian SSc population. AMA and anti-centromere antibodies are likely to indicate increasing risk of PBC in SSc patients.
- Subjects :
- Adult
Aged
Antigens, Nuclear immunology
Asian People
Autoantigens immunology
Comorbidity
Female
Humans
Japan epidemiology
Liver Cirrhosis, Biliary blood
Liver Cirrhosis, Biliary immunology
Male
Middle Aged
Mitochondria immunology
Nuclear Pore Complex Proteins immunology
Prevalence
Scleroderma, Systemic blood
Scleroderma, Systemic immunology
Autoantibodies blood
Liver Cirrhosis, Biliary epidemiology
Scleroderma, Systemic epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1439-7609
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Modern rheumatology
- Publication Type :
- Academic Journal
- Accession number :
- 22327744
- Full Text :
- https://doi.org/10.1007/s10165-012-0607-z