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Protective effects of aminoethyl-chitooligosaccharides against oxidative stress in mouse macrophage RAW 264.7 cells.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2012 Apr 01; Vol. 50 (3), pp. 624-31. Date of Electronic Publication: 2012 Feb 04. - Publication Year :
- 2012
-
Abstract
- The aim of this study is to investigate the inhibitory effects of aminoethyl-chitooligosaccharides (AE-COS) on oxidative stress in mouse macrophages (RAW 264.7 cells). The inhibitory effects of AE-COS on DNA and protein oxidation were studied in RAW 264.7 cells. Furthermore, free radical scavenging effect of AE-COS were determined in RAW264.7 cells by 2',7'-dichlorofluorescein (DCF) intensity and intracellular glutathione (GSH) level. AE-COS also inhibited myeloperoxidase (MPO) activity in human myeloid cells (HL-60). These results suggest that AE-COS acts as a potential free radical scavenger in RAW 264.7 cells.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Cell Survival drug effects
DNA genetics
DNA metabolism
Free Radical Scavengers chemistry
Free Radical Scavengers pharmacology
Glutathione metabolism
HL-60 Cells
Humans
Intracellular Space drug effects
Intracellular Space metabolism
Macrophages cytology
Macrophages enzymology
Membrane Proteins metabolism
Mice
Oxidation-Reduction drug effects
Peroxidase antagonists & inhibitors
Structure-Activity Relationship
Cytoprotection drug effects
Macrophages drug effects
Macrophages metabolism
Oligosaccharides chemistry
Oligosaccharides pharmacology
Oxidative Stress drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 50
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 22326422
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2012.01.036