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Xanthones from the stem bark of Garcinia bracteata with growth inhibitory effects against HL-60 cells.
- Source :
-
Phytochemistry [Phytochemistry] 2012 May; Vol. 77, pp. 280-6. Date of Electronic Publication: 2012 Feb 09. - Publication Year :
- 2012
-
Abstract
- Five xanthones, 1,4,5,6-tetrahydroxyxanthone (1) and bracteaxanthones III-VI (2-5) together with twenty-six known compounds (6-31), were isolated from the ethanol extract of the stem bark of Garcinia bracteata. Their structures were elucidated via spectroscopic analyses. Growth inhibitory activities of these compounds against the human leukaemic HL-60 cell line were measured in vitro. Compounds 7, 11, and 29 exhibited moderate activities with GI(50) values of 2.8, 3.4, and 3.1 μM, respectively, and a preliminary structure-activity relationship is discussed.<br /> (Copyright © 2012 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antineoplastic Agents, Phytogenic isolation & purification
Antineoplastic Agents, Phytogenic pharmacology
HL-60 Cells
Humans
Nuclear Magnetic Resonance, Biomolecular
Plant Bark chemistry
Plant Stems chemistry
Xanthones isolation & purification
Xanthones pharmacology
Antineoplastic Agents, Phytogenic chemistry
Garcinia chemistry
Xanthones chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 77
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22325589
- Full Text :
- https://doi.org/10.1016/j.phytochem.2012.01.010