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Cost effectiveness of prophylactic treatment with activated prothrombin complex concentrate in a patient with inhibitor-positive hemophilia A.
- Source :
-
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis [Blood Coagul Fibrinolysis] 2012 Apr; Vol. 23 (3), pp. 235-7. - Publication Year :
- 2012
-
Abstract
- Patients with hemophilia and high titers of inhibitors are hard to treat during bleeding events and consequently are more likely to incur high treatment costs and to experience deterioration in quality of life. We report here the case of a boy with hemophilia A and high titers of inhibitors who responded well to prophylactic activated prothrombin complex concentrate (APCC) treatment. Previously, he had to be hospitalized frequently because of painful bleeding of target joints of the knee and ankle. At the age of 4 years and 3 months, APCC prophylaxis at a dose of 60 U/kg, three times a week, was initiated together with on-demand therapy with recombinant factor VIIa. This reduced the frequency and severity of bleeding and ended the need for hospitalization. This, together with a decreased requirement for bypass agents, APCC treatment significantly reduced the cost of treatment for this patient.
- Subjects :
- Blood Coagulation Factor Inhibitors analysis
Blood Coagulation Factors administration & dosage
Blood Coagulation Factors therapeutic use
Child, Preschool
Cost-Benefit Analysis
Factor VIIa administration & dosage
Factor VIIa therapeutic use
Hemophilia A blood
Hemophilia A complications
Hemophilia A drug therapy
Hemorrhage blood
Hemorrhage complications
Hemorrhage drug therapy
Hospitalization
Humans
Joints drug effects
Male
Prothrombin analysis
Recombinant Proteins administration & dosage
Recombinant Proteins economics
Recombinant Proteins therapeutic use
Blood Coagulation Factors economics
Factor VIIa economics
Hemophilia A economics
Hemorrhage economics
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5733
- Volume :
- 23
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis
- Publication Type :
- Academic Journal
- Accession number :
- 22322137
- Full Text :
- https://doi.org/10.1097/MBC.0b013e32834fb582