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Cystatin C is associated with risk of venous thromboembolism in subjects with normal kidney function--the Tromsø study.
- Source :
-
Haematologica [Haematologica] 2012 Jul; Vol. 97 (7), pp. 1008-13. Date of Electronic Publication: 2012 Feb 07. - Publication Year :
- 2012
-
Abstract
- Background: Previous studies have shown an association between impaired kidney function, assessed by cystatin C-based estimated glomerular filtration rate, and venous thromboembolism. The aim of this study was to investigate whether serum cystatin C was associated with a risk of venous thromboembolism among subjects with normal kidney function in a prospective population-based study.<br />Design and Methods: Cystatin C was measured in serum from 3251 men and women with normal kidney function, aged 25-84 years, who participated in the Tromsø study in 1994-1995. Normal kidney function was defined as a creatinine-based estimated glomerular filtration rate greater than 90 mL/min/1.73 m(2) and absence of microalbuminuria. Incident venous thromboembolism was registered from the date of inclusion through to the end of follow-up, September 1, 2007. Cox-regression models were used to calculate hazard ratios with 95% confidence intervals for venous thromboembolism.<br />Results: There were 83 incident venous thromboembolic events, of which 53 (63.9 %) were provoked, during a median of 12.3 years of follow-up. A one standard deviation (0.11 mg/L) increase in serum cystatin C levels was associated with a 43% (hazard ratio 1.43; 95% confidence interval 1.17-1.72) increased risk of total venous thromboembolism. Subjects with cystatin C levels in the top quartile (≥ 0.87 mg/L) had a 2.5-fold (hazard ratio 2.51; 95% confidence interval 1.27-4.96) increased risk of venous thromboembolism compared to those with levels in the bottom quartile (≤ 0.72 mg/L) in adjusted analysis. The risk estimates were even higher for provoked venous thromboembolism (hazard ratio 3.11; 95% confidence interval 1.23-7.86).<br />Conclusions: Serum cystatin C levels were associated with the risk of venous thromboembolism in subjects with normal kidney function. Our findings suggest that elevated serum cystatin C levels may promote venous thrombosis beyond reflecting impaired kidney function.
- Subjects :
- Adult
Aged
Aged, 80 and over
Biomarkers blood
Creatinine urine
Female
Glomerular Filtration Rate
Humans
Kidney metabolism
Kidney physiopathology
Male
Middle Aged
Prognosis
Proportional Hazards Models
Prospective Studies
Risk
Cystatin C blood
Venous Thromboembolism blood
Venous Thromboembolism diagnosis
Venous Thromboembolism physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1592-8721
- Volume :
- 97
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Haematologica
- Publication Type :
- Academic Journal
- Accession number :
- 22315498
- Full Text :
- https://doi.org/10.3324/haematol.2011.057653