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Circulating adipocyte fatty acid-binding protein, juvenile obesity, and metabolic syndrome.
- Source :
-
Journal of pediatric endocrinology & metabolism : JPEM [J Pediatr Endocrinol Metab] 2011; Vol. 24 (11-12), pp. 921-8. - Publication Year :
- 2011
-
Abstract
- Adipocyte fatty acid-binding protein (A-FABP) links obesity and metabolic syndrome (MetS) and might be targeted in future therapies. Its utility as a MetS biomarker has been suggested in adults but has not been examined in children/adolescents. Our objectives were to identify metabolic parameters associated with A-FABP elevation in children and adolescents and to evaluate the effect of obesity intervention and A-FABP diagnostic utility. A-FABP and anthropometric, metabolic, and inflammatory indices were measured in 31 lean and 114 overweight/obese children and adolescents and reassessed after obesity intervention (1 year; diet and enhanced physical activity, with or without metformin). A-FABP was significantly higher in overweight/ obese than lean individuals, where it correlated with insulin, waist circumference (WC), and 2-h glucose independent of body mass index (BMI), age, gender, and developmental stage. The pattern of A-FABP associations differed between sexes. As a MetS indicator, A-FABP had 68% accuracy. The weight reduction program was effective in reducing A-FABP, BMI%, WC, triglycerides, and cholesterol. In conclusion, elevation in A-FABP is associated with MetS components independent of BMI status and can be reduced by diet and enhanced physical activity. A-FABP as a single MetS biomarker has a moderate accuracy.
- Subjects :
- Adolescent
Biomarkers blood
Case-Control Studies
Child
Cohort Studies
Diet, Reducing
Female
Humans
Hyperinsulinism metabolism
Male
Metabolic Syndrome diet therapy
Obesity diet therapy
Overweight diet therapy
Overweight metabolism
Adipocytes metabolism
Fatty Acid-Binding Proteins blood
Metabolic Syndrome diagnosis
Metabolic Syndrome metabolism
Obesity metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0334-018X
- Volume :
- 24
- Issue :
- 11-12
- Database :
- MEDLINE
- Journal :
- Journal of pediatric endocrinology & metabolism : JPEM
- Publication Type :
- Academic Journal
- Accession number :
- 22308843
- Full Text :
- https://doi.org/10.1515/jpem.2011.323