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[Dependence of IgG titers specific to various hepatitis C virus proteins on features of chronic infection course].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 2011 Nov-Dec (6), pp. 57-61. - Publication Year :
- 2011
-
Abstract
- Aim: Analysis of IgG titers that are specific to various hepatitis C proteins depending on features of chronic infection course.<br />Materials and Methods: Qualitative analysis of levels of IgG specific to a number of hepatitis C virus proteins was performed in 30 patients and 30 virus carriers.<br />Results: Significant differences between these HCV infection course variants by level of accumulation of all studied HCV antibody groups were detected. Low a-core and a-NS4 IgG, high a-NS3 and medium a-NS5 titers may be an indicator of HCV carriage. Medium and high a-core, medium a-NS3 and a-NS4 as well as higher a-NS5 titers indicate chronic hepatitis C.<br />Conclusion: The proposed method can be used for screening of chronic HCV infection course in the clinical practice.
- Subjects :
- Adult
Carrier State
Female
Hepacivirus genetics
Hepacivirus isolation & purification
Hepatitis C Antibodies analysis
Hepatitis C, Chronic immunology
Hepatitis C, Chronic physiopathology
Hepatitis C, Chronic virology
Humans
Immunoassay
Immunoglobulin G analysis
Male
Middle Aged
RNA, Viral immunology
Research Design
Viral Nonstructural Proteins analysis
Viral Nonstructural Proteins immunology
Hepacivirus immunology
Hepatitis C Antibodies immunology
Hepatitis C Antigens immunology
Hepatitis C, Chronic diagnosis
Immunoglobulin G immunology
Viral Core Proteins immunology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 22308730