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Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission.
- Source :
-
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases [Infect Genet Evol] 2012 Mar; Vol. 12 (2), pp. 428-34. Date of Electronic Publication: 2012 Jan 28. - Publication Year :
- 2012
-
Abstract
- Hepatitis E is considered as a public health problem in China. To determine the overall molecular epidemiology of hepatitis E virus (HEV) and analyze the situation of cross-species transmission between humans and swine in China over the last 25 years (1986-2011), 626 HEV complete and partial sequences (89 isolates identified by our group) isolated from humans and animals in China were retrieved from GenBank and subjected to phylogenetic analysis. There were three genotypes and 11 sub-genotypes of HEV prevailing in China. Furthermore, rabbit HEVs, of which the genotype is controversial, are also widespread in China. Genotype 1 was the most isolated genotype prior to 2000 and mainly detected in Xinjiang, Beijing and East China. However, genotype 4, which was identified in most regions of China during the last 10 years, has overtaken genotype 1 in frequency of isolation nationwide. Genotype 3 HEV strains have been found only in eastern China and were thought to be imported from Japan. Both genotypes 3 and 4 were found in humans and swine and cross-species transmission from pigs to humans of the two genotypes may have occurred in Northeast, Northwest, North, East and South China. These results indicate that HEV strains with considerable genetic diversity are widespread and the zoonotic transmission between swine and humans appears ubiquitous in China.<br /> (Copyright © 2012 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
China epidemiology
Hepatitis E virology
Hepatitis E virus genetics
Hepatitis E virus isolation & purification
Humans
Phylogeography
RNA, Viral chemistry
Rabbits
Sequence Analysis, DNA
Swine
Zoonoses epidemiology
Genetic Variation
Genotype
Hepatitis E epidemiology
Hepatitis E transmission
Hepatitis E virus classification
Phylogeny
Zoonoses virology
Subjects
Details
- Language :
- English
- ISSN :
- 1567-7257
- Volume :
- 12
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 22306814
- Full Text :
- https://doi.org/10.1016/j.meegid.2012.01.017