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Fucoxanthin promotes translocation and induction of glucose transporter 4 in skeletal muscles of diabetic/obese KK-A(y) mice.
- Source :
-
Phytomedicine : international journal of phytotherapy and phytopharmacology [Phytomedicine] 2012 Mar 15; Vol. 19 (5), pp. 389-94. Date of Electronic Publication: 2012 Feb 02. - Publication Year :
- 2012
-
Abstract
- Fucoxanthin (Fx) isolated from Undaria pinnatifida suppresses the development of hyperglycemia and hyperinsulinemia of diabetic/obese KK-A(y) mice after 2 weeks of feeding 0.2% Fx-containing diet. In the soleus muscle of KK-A(y) mice that were fed Fx, glucose transporter 4 (GLUT4) translocation to plasma membranes from cytosol was promoted. On the other hand, Fx increased GLUT4 expression levels in the extensor digitorum longus (EDL) muscle, although GLUT4 translocation tended to increase. The expression levels of insulin receptor (IR) mRNA and phosphorylation of Akt, which are in upstream of the insulin signaling pathway regulating GLUT4 translocation, were also enhanced in the soleus and EDL muscles of the mice fed Fx. Furthermore, Fx induced peroxisome proliferator activated receptor γ coactivator-1α (PGC-1α), which has been reported to increase GLUT4 expression, in both soleus and EDL muscles. These results suggest that in diabetic/obese KK-A(y) mice, Fx improves hyperglycemia by activating the insulin signaling pathway, including GLUT4 translocation, and inducing GLUT4 expression in the soleus and EDL muscles, respectively, of diabetic/obese KK-A(y) mice.<br /> (Copyright © 2011 Elsevier GmbH. All rights reserved.)
- Subjects :
- Animals
Biological Transport drug effects
Blood Glucose analysis
Cell Membrane metabolism
Diabetes Mellitus blood
Female
Glucose Transporter Type 4 metabolism
Insulin blood
Mice
Mice, Obese
Mice, Transgenic
Muscle, Skeletal drug effects
Obesity blood
Obesity therapy
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
RNA, Messenger genetics
Receptor, Insulin genetics
Transcription Factors genetics
Xanthophylls chemistry
Xanthophylls isolation & purification
Blood Glucose metabolism
Diabetes Mellitus therapy
Glucose Transporter Type 4 drug effects
Muscle, Skeletal metabolism
Undaria chemistry
Xanthophylls pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1618-095X
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Phytomedicine : international journal of phytotherapy and phytopharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 22305278
- Full Text :
- https://doi.org/10.1016/j.phymed.2011.11.001