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[State of acute phase markers and oxidative stress in patients with kidney stones in the urinary tract].
- Source :
-
Actas urologicas espanolas [Actas Urol Esp] 2012 May; Vol. 36 (5), pp. 296-301. Date of Electronic Publication: 2012 Feb 01. - Publication Year :
- 2012
-
Abstract
- Objective: This present study has aimed to assess the state of acute phase markers and oxidative stress in patients with kidney stones.<br />Material and Methods: A prospective study was carried out on 100 patients with kidney stones and 25 healthy controls. Albumin, ß2 microglobulin, Gamma-glutamyl transpepsidase, Lactate dehydrogenase, Tumor necrosis factor alpha, Interleukin 1 and Interleukin-6 were evaluated as acute phase markers and lipid peroxidation products, Superoxide dismutase and Glutathione peroxidase levels acted as oxidative stress markers.<br />Results: An increase in renal cell damage markers as expressed by the ß2 microglobulin (p=0.04), albumin (p=0.004), Lactate dehydrogenase (p=0.001) and Gamma glutamyl transpepsidasa (p=0.01) was observed in the patient group. There was a direct correlation between levels of ß2 microglobulin and stone size (r=0.3, p=0.03). The association between stone size and cytokine activation was observed to be stronger in patients with staghorn calculi. In these patients, Tumor necrosis factor alpha (p=0.011), Interleukin 1 (p=0.004) and Interleukin 6 (p=0.004) were significantly higher. Patients with stones in the urinary tract showed data of significantly higher oxidative stress, expressed as an increase in levels of lipid peroxidation products (p=0.03) and a decrease in the antioxidant activity of Superoxide dismutase (p=0.03) and Glutathione peroxidase (p=0.002).<br />Conclusions: Patients undergoing urolithiasis showed an elevation of acute phase markers, associated with oxidative stress as expressed by an increase in lipid peroxidation products and a decrease in the antioxidant enzyme activity.<br /> (Copyright © 2011 AEU. Published by Elsevier Espana. All rights reserved.)
Details
- Language :
- Spanish; Castilian
- ISSN :
- 1699-7980
- Volume :
- 36
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Actas urologicas espanolas
- Publication Type :
- Academic Journal
- Accession number :
- 22301017
- Full Text :
- https://doi.org/10.1016/j.acuro.2011.08.004