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Action of metronidazole on Entamoeba histolytica: an ultrastructural study.

Authors :
Agrawal A
Maitra SC
Arya A
Sagar P
Source :
The Journal of communicable diseases [J Commun Dis] 1990 Mar; Vol. 22 (1), pp. 47-54.
Publication Year :
1990

Abstract

Metronidazole (19 micrograms/ml) caused progressive increase in vacuolization in Entamoeba histolytica cells with disintegration of its plasma membrane leading to almost complete disappearance of the latter within 3 hours. The drug also induced formation of helical ribosomal aggregates in the cytoplasm and disappearance of button like structures inside the nucleus.

Subjects

Subjects :
Animals
Cell Membrane drug effects
Cell Nucleus drug effects
Entamoeba histolytica ultrastructure
Microscopy, Electron
Vacuoles drug effects
Entamoeba histolytica drug effects
Metronidazole pharmacology

Details

Language :
English
ISSN :
0019-5138
Volume :
22
Issue :
1
Database :
MEDLINE
Journal :
The Journal of communicable diseases
Publication Type :
Academic Journal
Accession number :
2230021

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Authors Abstract Subjects Details