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Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets.
- Source :
-
Kidney international [Kidney Int] 2012 Jun; Vol. 81 (11), pp. 1116-22. Date of Electronic Publication: 2012 Feb 01. - Publication Year :
- 2012
-
Abstract
- Calcium balance in chronic kidney disease is poorly understood as calcium deficiency is a stimulus for secondary hyperparathyroidism and consequent bone loss while calcium excess promotes extraosseous calcifications. To help resolve this, we evaluated calcium balance in normal individuals and in patients with chronic kidney disease (CKD) on daily diets containing 800 and 2000 mg elemental calcium. Both normal individuals and patients with late stage 3 and stage 4 CKD were in slightly negative to neutral calcium balance on the 800-mg calcium diet. Normal individuals were in modest positive calcium balance on the 2000-mg diet, while patients with CKD on the same diet were in marked positive calcium balance at least over the 9 days of study; and significantly greater than the normal individuals. Increased calcium intake significantly decreased 1,25-dihydroxy-vitamin D and intact parathyroid hormone levels but did not alter the serum calcium concentration. Thus, our findings have important implications for both preventing calcium deficiency and loading in individuals with late stage 3 and stage 4 CKD.
- Subjects :
- Adult
Aged
Biomarkers blood
Calcium deficiency
Calcium, Dietary administration & dosage
Chronic Disease
Colorado
Creatinine blood
Cross-Over Studies
Female
Glomerular Filtration Rate
Homeostasis
Humans
Kidney metabolism
Kidney physiopathology
Kidney Diseases complications
Kidney Diseases physiopathology
Male
Middle Aged
Nutrition Policy
Parathyroid Hormone blood
Severity of Illness Index
Time Factors
Vitamin D analogs & derivatives
Vitamin D blood
Calcium blood
Calcium, Dietary blood
Kidney Diseases blood
Subjects
Details
- Language :
- English
- ISSN :
- 1523-1755
- Volume :
- 81
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Kidney international
- Publication Type :
- Academic Journal
- Accession number :
- 22297674
- Full Text :
- https://doi.org/10.1038/ki.2011.490