An alternative approach to para-C-H arylation of phenol: palladium-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives.

An efficient approach to prepare para-aryl phenols has been developed by using a Pd-catalyzed tandem γ-arylation/aromatization of 2-cyclohexen-1-one derivatives with aryl bromides. This approach provides various p-aryl phenols from the phenol surrogates, 2-cyclohexen-1-one derivatives, in a single reaction step on the basis of C-H arylation.