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P1 (adenosine) purinoceptor assays.

Authors :
Mustafa SJ
Ansari HR
Abebe W
Source :
Current protocols in pharmacology [Curr Protoc Pharmacol] 2009 Jun; Vol. Chapter 4, pp. Unit 4.7.
Publication Year :
2009

Abstract

P1 purinoceptors, or adenosine (ADO) receptors, mediate the biological effects of the endogenous nucleoside, ADO and its analogs. ADO works through four receptor subtypes: A(1), A(2A), A(2B), and A(3). Isolated tissue assays used for the pharmacological characterization of ADO receptors based on functional responses are described in this unit. The guinea pig atrium, pig coronary artery, guinea pig aorta ,and mouse aorta have been used for the characterization of ADO receptor subtypes.

Subjects

Subjects :
Animals
Aorta drug effects
Coronary Vessels drug effects
Guinea Pigs
Heart Atria drug effects
Mice
Specimen Handling
Sus scrofa
Biological Assay methods
Purinergic P1 Receptor Agonists pharmacology
Purinergic P1 Receptor Antagonists pharmacology
Receptors, Purinergic P1 drug effects

Details

Language :
English
ISSN :
1934-8290
Volume :
Chapter 4
Database :
MEDLINE
Journal :
Current protocols in pharmacology
Publication Type :
Academic Journal
Accession number :
22294395
Full Text :
https://doi.org/10.1002/0471141755.ph0407s45
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