Epstein-Barr virus neutralizing antibody levels and risk of multiple sclerosis.

Authors :: Simon KC
O'Reilly EJ
Munger KL
Finerty S
Morgan AJ
Ascherio A
Source :: Multiple sclerosis (Houndmills, Basingstoke, England) [Mult Scler] 2012 Aug; Vol. 18 (8), pp. 1185-7. Date of Electronic Publication: 2012 Jan 30.
Publication Year :: 2012
Abstract: Previous infection with Epstein-Barr virus (EBV) and infectious mononucleosis are established multiple sclerosis (MS) risk factors, and elevated serum titers of anti-EBV nuclear antigen (anti-EBNA) antibodies in healthy adults are strongly correlated with future MS risk. In this prospective study, we investigated the association between EBV neutralizing antibodies and MS risk. MS risk tended to be higher in individuals with high titers of neutralizing antibodies compared to those with low titers (relative risk [RR] = 2.2, 95% confidence interval [CI] 0.97-5.1). This association was attenuated after adjustment for anti-EBNA1 IgG Ab titers (RR = 1.4, 95% CI 0.5-3.5). This preliminary finding warrants further study in a larger population.