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[Mice are not Men and yet… how humanized mice inform us about human infectious diseases].
- Source :
-
Medecine sciences : M/S [Med Sci (Paris)] 2012 Jan; Vol. 28 (1), pp. 63-8. Date of Electronic Publication: 2012 Jan 27. - Publication Year :
- 2012
-
Abstract
- The study of human pathologies is often limited by the absence of animal models which are robust, cost-effective and reproduce the hallmarks of human infections. While mice have been frequently employed to study human diseases, many of important pathogens display unique human tropism. These last two decades the graft of human progenitor cells or tissues into -immunodeficient mice has allowed the elaboration of so called humanized mice. Humanized mouse technology has made rapid progress, and it is now possible to achieve high levels of human chimerism in various organs and tissues, particularly the immune system and the liver. The review briefly summarizes the different models of humanized mice available for in vivo experiments. With a focus on lymphotropic, monocytotropic and hepatotropic viruses, we here discuss the current status and future prospects of these models for studying the pathogenesis of infectious diseases. Furthermore, they provide a powerful tool for the development of innovative therapies.<br /> (© 2012 médecine/sciences – Inserm / SRMS.)
- Subjects :
- Animals
Crosses, Genetic
DNA-Binding Proteins deficiency
DNA-Binding Proteins genetics
Forecasting
Hepatocytes transplantation
Humans
Immunologic Deficiency Syndromes genetics
Immunologic Deficiency Syndromes immunology
Interleukin Receptor Common gamma Subunit deficiency
Interleukin Receptor Common gamma Subunit genetics
Liver embryology
Liver Transplantation
Mice
Mice, Inbred BALB C
Radiation Chimera
Species Specificity
Thymus Gland embryology
Thymus Gland transplantation
Transplantation, Heterologous
Virus Diseases drug therapy
Virus Diseases immunology
Virus Diseases virology
Chimera genetics
Chimera immunology
Communicable Diseases
Disease Models, Animal
Mice, Mutant Strains genetics
Mice, Mutant Strains immunology
Subjects
Details
- Language :
- French
- ISSN :
- 0767-0974
- Volume :
- 28
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Medecine sciences : M/S
- Publication Type :
- Academic Journal
- Accession number :
- 22289832
- Full Text :
- https://doi.org/10.1051/medsci/2012281018