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Synthesis and antimalarial activity of dihydroperoxides and tetraoxanes conjugated with bis(benzyl)acetone derivatives.
- Source :
-
Chemical biology & drug design [Chem Biol Drug Des] 2012 May; Vol. 79 (5), pp. 790-7. Date of Electronic Publication: 2012 Mar 16. - Publication Year :
- 2012
-
Abstract
- Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 μm ≤ IC(50) ≤ 5.0 μm) against blood forms of the human malaria parasite Plasmodium falciparum.<br /> (© 2012 John Wiley & Sons A/S.)
- Subjects :
- Acetone chemical synthesis
Acetone chemistry
Acetone pharmacology
Antimalarials chemical synthesis
Humans
Inhibitory Concentration 50
Malaria, Falciparum drug therapy
Peroxides chemical synthesis
Structure-Activity Relationship
Tetraoxanes chemical synthesis
Antimalarials chemistry
Antimalarials pharmacology
Peroxides chemistry
Peroxides pharmacology
Plasmodium falciparum drug effects
Tetraoxanes chemistry
Tetraoxanes pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1747-0285
- Volume :
- 79
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Chemical biology & drug design
- Publication Type :
- Academic Journal
- Accession number :
- 22284812
- Full Text :
- https://doi.org/10.1111/j.1747-0285.2012.01345.x