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Novel inhibitors of nitric oxide synthase with antioxidant properties.
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2012 Mar; Vol. 49, pp. 118-26. Date of Electronic Publication: 2012 Jan 11. - Publication Year :
- 2012
-
Abstract
- We previously described a series of imidazole-based inhibitors substituted at N-1 with an arylethanone chain as interesting inhibitors of neuronal nitric oxide synthase (nNOS), endowed with good selectivity vs endothelial nitric oxide synthase (eNOS). As a follow up of these studies, several analogs characterized by the presence of substituted imidazoles or other mono or bicyclic nitrogen-containing heterocycles instead of simple imidazole were synthesized, and their biological evaluation as in vitro inhibitors of both nNOS and eNOS is described herein. Most of these compounds showed improved nNOS and eNOS inhibitory activity with respect to reference inhibitors. Selected compounds were also tested to analyze their antioxidant properties. Some of them displayed good capacity to scavenge free radicals and ability to reduce lipid peroxidation.<br /> (Copyright © 2012 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Animals
Humans
Imidazoles chemistry
Imidazoles pharmacology
Lipid Peroxidation drug effects
Nitric Oxide Synthase Type I metabolism
Nitric Oxide Synthase Type III metabolism
Rats
Antioxidants chemistry
Antioxidants pharmacology
Enzyme Inhibitors chemistry
Enzyme Inhibitors pharmacology
Nitric Oxide Synthase Type I antagonists & inhibitors
Nitric Oxide Synthase Type III antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 49
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 22280820
- Full Text :
- https://doi.org/10.1016/j.ejmech.2012.01.002