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Savene® (dexrazoxane) use in clinical practice.
- Source :
-
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer [Support Care Cancer] 2012 May; Vol. 20 (5), pp. 1109-12. Date of Electronic Publication: 2012 Jan 27. - Publication Year :
- 2012
-
Abstract
- Introduction: Anthracycline extravasation (ACEV) is a rare but potentially devastating event which can result in severe injuries including ulceration and necrosis, slow-healing lesions, serious joint damage and permanent disfigurement. It can delay further scheduled chemotherapy and affect cancer treatment outcome. Savene® (dexrazoxane) is the only approved antidote for ACEV in Europe (Totect® in the USA) and is administered by intravenous infusion. Its efficacy has been demonstrated in clinical trials with biopsy-verified ACEV with a 98% success rate (no need for surgical debridement) allowing for immediate continuation of chemotherapy in 71% of patients. Adverse events, mainly haematological toxicity, were rapidly reversible. The objective of the study was to assess, in clinical practice, the efficacy and safety profile of Savene® for ACEV in different Belgian hospitals.<br />Patients and Methods: A survey of Savene® use was conducted in Belgium from 2007 to 2010 by using a questionnaire sent to 44 hospitals.<br />Main Results: Data were obtained for 41 cancer patients, 68% (28/41) had ACEV from central venous catheters. Surgical debridement due to ACEV could be avoided in 26 out of 28 extravasations from a central venous access and in 95% (39/41) of the total population treated with Savene®. Planned chemotherapy was maintained in 73% (30/41) of patients. Eight adverse events were reported in four patients treated with Savene®, six events were assessed to be of common toxicity criteria grades 1-2 (nausea, leucopenia and arm pain) and two events (neutropenia and pancytopenia) were assessed to be grade 3.<br />Conclusion: These data are comparable with the data from previous clinical trials and confirm the efficacy and safety profile of Savene® in clinical practice for the treatment of anthracycline extravasation, including extravasations from central venous catheters.
- Subjects :
- Anthracyclines therapeutic use
Antibiotics, Antineoplastic adverse effects
Antibiotics, Antineoplastic therapeutic use
Belgium
Catheterization, Central Venous
Chelating Agents adverse effects
Data Collection
Debridement methods
Extravasation of Diagnostic and Therapeutic Materials pathology
Humans
Neoplasms drug therapy
Razoxane adverse effects
Retrospective Studies
Surveys and Questionnaires
Treatment Outcome
Anthracyclines adverse effects
Chelating Agents therapeutic use
Extravasation of Diagnostic and Therapeutic Materials drug therapy
Razoxane therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1433-7339
- Volume :
- 20
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 22278308
- Full Text :
- https://doi.org/10.1007/s00520-012-1382-2