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Hepatoportal sclerosis: CT and MRI appearance with histopathologic correlation.
- Source :
-
AJR. American journal of roentgenology [AJR Am J Roentgenol] 2012 Feb; Vol. 198 (2), pp. 370-6. - Publication Year :
- 2012
-
Abstract
- Objective: The purposes of this study were to describe the spectrum of cross-sectional imaging findings of pathologically proven hepatoportal sclerosis and to compare the features of advanced and nonadvanced hepatoportal sclerosis.<br />Materials and Methods: Eighteen patients with a histopathologic diagnosis of hepatoportal sclerosis who had concurrent MRI or CT images participated in the study. The following imaging features were assessed: presence of liver nodularity and liver lesions, portal vein patency, presence and degree of portal hypertension, liver volume, and caudate-to-right lobe ratio. These features were compared between patients who underwent transplant and those who did not.<br />Results: The 18 patients (11 men and one boy, six women; mean age, 46.5 years) had hepatoportal sclerosis confirmed with liver biopsy (14 patients) or explant (four patients). Fourteen patients underwent contrast-enhanced MRI, and five underwent CT. The imaging findings were as follows: liver surface nodularity, five patients (all four transplant, one nontransplant) (p = 0.0016); evidence of portal hypertension, 17 patients; increased caudate-to-right lobe ratio, 16 patients; high periportal signal intensity on T2-weighted images, six patients; portal vein occlusion with cavernous transformation, five patients. The transplant patients had smaller pretransplant liver volume than did nontransplant patients (p < 0.04).<br />Conclusion: Hepatoportal sclerosis is characterized by caudate lobe hypertrophy and right hepatic lobe atrophy, preserved liver volume, and lack of the liver nodularity associated with portal hypertension. In advanced cases, liver nodularity and atrophy produce an imaging appearance indistinguishable from that of cirrhosis.
- Subjects :
- Adolescent
Adult
Aged
Child
Contrast Media
Female
Gadolinium DTPA
Humans
Hypertension, Portal diagnosis
Hypertension, Portal diagnostic imaging
Hypertension, Portal pathology
Liver Diseases diagnostic imaging
Liver Diseases pathology
Liver Function Tests
Male
Middle Aged
Retrospective Studies
Sclerosis
Liver Diseases diagnosis
Magnetic Resonance Imaging
Portal System pathology
Tomography, X-Ray Computed
Subjects
Details
- Language :
- English
- ISSN :
- 1546-3141
- Volume :
- 198
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- AJR. American journal of roentgenology
- Publication Type :
- Academic Journal
- Accession number :
- 22268180
- Full Text :
- https://doi.org/10.2214/AJR.11.6855